Database : HANSEN Search on : MODELOS ESTATISTICOS [Subject descriptor] References found : 4 [refine] Displaying: 1 .. 4   in format [Detailed]

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Id: 18287 Author: Wallace, Chris; Clayton, David Title: Estimating the relative recurrence risk ratio using a global cross-ratio model ..- Source: s.l; s.n; 2003. 10 p. tab, graf. Abstract: The relative recurrence risk ratio lambdaR (and particularly the sibling recurrence risk ratio, lambdaS) is often of interest to those wanting to quantify the genetic contribution towards risk of disease or to discriminate between different genetic models. However, estimating lambdaR for complex diseases for which genetic and environmental risk factors are both involved is not straightforward. Ignoring environmental factors may lead to inflated estimates of lambdaR. We present a marginal model which uses a copula function to model the association in cumulative incidence rates between pairs of relatives. This model is applicable to present-state data and allows estimation of risk of disease in a pair of relatives (and hence lambdaR), given measured environmental covariates. We apply the model to leprosy among sibling pairs from the Karonga district, Malawi. If risk factors are ignored, the apparent lambdaS in this population is over 3. Accounting for known nongenetic risk factors reduces it to just under 2. (AU). Descriptors: MODELOS TEORICOS MODELOS DE RISCOS PROPORCIONAIS MODELOS LOG-LINEARES (SAUDE PÚBLICA) MODELOS ESTATISTICOS HANSENIASE DIMORFA/imunol HANSENIASE DIMORFA/microbiol HANSENIASE DIMORFA/transm HANSENIASE VIRCHOWIANA/imunol HANSENIASE VIRCHOWIANA/microbiol HANSENIASE VIRCHOWIANA/transm HANSENIASE TUBERCULOIDE/imunol HANSENIASE TUBERCULOIDE/microbiol HANSENIASE TUBERCULOIDE/transm HANSENIASE/clas HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/transm - MODELOS MATEMATICOS  RAZAO DE DIFERENCA  RISCO RELATIVO (SAUDE PÚBLICA)  MEDICAO DE RISCO/estatíst  MEDICAO DE RISCO/tend  VACINA BCG/uso terap  COMUNICANTE/estatíst Limits: HUMANO Location: BR191.1; 00723/s

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Id: 13723 Author: Meima, Abraham; Irgens, Lorentz M; Van Oortmarssen, Gerrit J; Richardus, Jan H; Habbema, Dik F Title: Disappearance of leprosy from Norway: an exploration of critical factors using an epidemiological modelling approach ..- Source: s.l; s.n; 2002. 10 p. ilus, tab, graf. Abstract: BACKGROUND: By the middle of the 19th century, leprosy was a serious public health problem in Norway. By 1920, new cases only rarely occurred. This study aims to explain the disappearance of leprosy from Norway. METHODS: Data from the National Leprosy Registry of Norway and population censuses were used. The patient data include year of birth, onset of disease, registration, hospital admission, death, and emigration. The Norwegian data were analysed using epidemiological models of disease transmission and control. RESULTS: The time trend in leprosy new case detection in Norway can be reproduced adequately. The shift in new case detection towards older ages which occurred over time is accounted for by assuming that infected individuals may have a very long incubation period. The decline cannot be explained fully by the Norwegian policy of isolation of patients: an autonomous decrease in transmission, reflecting improvements in for instance living conditions, must also be assumed. The estimated contribution of the isolation policy to the decline in new case detection very much depends on assumptions made on build-up of contagiousness during the incubation period and waning of transmission opportunities due to rapid transmission to close contacts. CONCLUSION: The impact of isolation on interruption of transmission remains uncertain. This uncertainty also applies to contemporary leprosy control that mainly relies on chemotherapy treatment. Further research is needed to establish the impact of leprosy interventions on transmission. (AU). Descriptors: SIMULACAO POR COMPUTADOR HANSENIASE/epidemiol HANSENIASE/prev HANSENIASE/transm ISOLAMENTO DE PACIENTES NORUEGA/epidemiol - MODELOS ESTATISTICOS  SISTEMA DE REGISTROS Limits: HUMANO CRIANÇA ADULTO MEIA-IDADE IDOSO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09039/s

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Id: 10114 Author: Lietman, Tom; Porco, Travis; Blower, Sally Title: Leprosy and tuberculosis: the epidemiological consequences of cross-immunity (Commentary) ..- Source: s.l; s.n; 1997. 5 p. ilus. Descriptors: CAUSA DA MORTE COMORBILIDADE REAÇOES CRUZADAS AVANÇO DA DOENÇA IMUNIDADE ATIVA INCIDENCIA HANSENIASE HANSENIASE HANSENIASE MODELOS ESTATISTICOS REPRODUTIBILIDADE DE RESULTADOS FATORES DE TEMPO TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 07055/s

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Id: 9992 Author: Shah, S; Green, J. R Title: Testing for haplotype concordance with incomplete parental data-madified Q and correction for odified N ..- Source: s.l; s.n; 1993. 9 p. tab. Descriptors: SUSCETIBILIDADE A DOENÇA FAMILIA GENÉTICA MÉDICA HAPLOTIPOS HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE MATEMATICA MODELOS GENÉTICOS MODELOS ESTATISTICOS PAIS PROBABILIDADE Location: BR191.1; 06636/s

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